Institute of Process Engineering, Chinese Academy of Sciences
State Key Laboratory of Biochemical Engineering

Lab Members

Assistant Professor

Yan Li

Ph. D, Assistant Professor 

National Key Laboratory of Biochemical Engineering

Institute of Process Engineering

Chinese Academy of Sciences, 100190, Beijing, P. R. China

Tel:  (+86) 10 8254 4990


Research Interest:

Biomaterials; Drug delivery; Stem cell therapy


20102015: Ph.D. in Biochemical Engineering: University of Chinese Academy of Science, CHINA            

20062010: B.S. in Chemistry: University of Science and Technology, CHINA

Professional Experience:

2015Present: Assistant Professor, Institute of Process Engineering, Chinese Academy of Sciences, CHINA


  1. Zhang Ran1, Li Yan1, Hu Bing Bing, Lu Zhi Guo, Zhang Jin Chao*, Zhang Xin*. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy. Advanced Materials, 2016, 28: 6345-6352. (IF=19.791)

  2. Li Yan, Zhang Ruilong, Lu Zhiguo, Ma Guanghui, Chen Lei, Tang Qunwei*, Zhang Xin*. Microenvironment responsive three-pronged approach breaking traditional chemotherapy to target cancer stem cells for synergistic inoperable large tumor therapy. Small, 2016, 40: 5516-5523. (IF=8.643)

  3. Li Yan1, Liu Ruiyuan1, Yang Jun, Shi Yuanjie, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior. Biomaterials, 2015, 41: 1-14. (IF= 8.402) 

  4. Li Yan1, Liu Ruiyuan1, Shi Yuanjie, Zhang Zhenzhong*, Zhang Xin*. Zwitterionic poly(carboxybetaine) based cationic liposomes enhancing tumor therapy without accelerated blood clearance phenomenon. Theranostics, 2015, 5: 583-596. (IF= 8.712)

  5. Li Yan, Liu Ruiyuan, Yang Jun, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy. Biomaterials, 2014, 35, 9731-9745. (IF= 8.402) 

  6. Li Yan1, Cheng Qiang1, Jiang Qian, Huang Yuanyu, Liu Hongmei, Zhao Yuliang, Cao Weipeng, Ma Guanghui, Dai Fengying*, Liang Xingjie*, Liang Zicai*, Zhang Xin*. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. Journal of Controlled Release, 2014, 176: 104-114. (IF= 7.786) 

Zhang Lab, Add: No.1, Bei-Er-Tiao, Zhong-Guan-Cun, Haidian District, Beijing China | Phone:+86-10-82544853 | Page view | 备案号:京ICP备17047136号