Institute of Process Engineering, Chinese Academy of Sciences
State Key Laboratory of Biochemical Engineering

Professor Xin Zhang

Vice-Director, State Key Lab. of Biochemical Engineering
Professor, PI, 国家杰青 
National Key Laboratory of Biochemical Engineering
Institute of Process Engineering
Chinese Academy of Sciences, 100190, Beijing, P. R. China
Tel: (+86) 10 8254 4853
Fax: (+86) 10 8254 4853
Group Website:

Research Interest:
Biomaterials; Drug delivery; Diagnostic imaging; Vaccine adjuvant; Stem cell therapy

2004-2008: Ph.D. in Life Science: University of Strasbourg, FRANCE
2001-2004: M.S. in Materials: Tianjin University, CHINA
1997-2001: B.S. in Polymer Materials: Tianjin University, CHINA
Professional Experience:
2010-Present: Professor, Institute of Process Engineering, Chinese Academy of Sciences, CHINA
2008-2010: Assistant Professor, INSERM, FRANCE

Contributions within Five Years:
More than 80 research papers published in peer-reviewed journals, including Advanced Materials, Signal Transduction and Targeted TherapyACS NanoJACS, and Science Advances, which have been cited overall more than 1800 times; one Chinese Book chapter entitled "Gene therapy drug mimetic membrane system" and one English Book chapter entitled " Lipopolyplex nanoparticles for tumor targeting theranostics " published at 2013 by Science Press, China, and 2014 by Higher Education Press, China, respectively; 15 patents.The membership of Editorial Board of Theranostics and Bioactive Materials. Themember of the council of “Nanobiology Academic Subgroup, Biophysical Society of China”. Themember of the youth committee of “Chinese Society for Biomaterials”. “Young Scientist Award” by “Chinese Society for Biomaterials” in 2018, “Young Innovator Award in Nanobiotechnology” by Nano Research in 2018, “First Prize of Ministerial and Provincial-Level Science and Technology Awards” in 2020“Second Prize of Beijing Natural Science” in 2021.

Professional Affiliations:
Membership: American Chemical Society
Committee Membership: Chinese Society for Biomaterials
Committee Membership: Chinese Society of Biomedical Engineering


  • (1)Zhiguo Lu*, Jie Shen, Jun Yang, Jingwen Wang, Ruichen Zhao, Tianlu Zhang, Jing Guo, Xin Zhang*, Nucleic acid drug vectors for diagnosis and treatment of brain diseases. Signal Transduction and Targeted Therapy. 2023, 8, 1, 39. (IF 38.12)

  • (2)Jie Shen#, Zhiguo Lu#, Jianze Wang, Qiulian Hao, Weihong Ji, Yanyue Wu, Huan Peng, Ruichen Zhao, Jun Yang, Yan Li, Zhuyan Shi, Xin Zhang*. Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment. Advanced Materials, 2021, 33, 27, 2101993. (IF=32.09) 

  • (3)Weihong Ji#, Yan Li#, Huan Peng, Ruichen Zhao, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Zhiguo Lu, Jun Yang, Xin Zhang*. Self-catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases. Advanced Materials, 2021,34,1,2105711. (IF=32.09) 

  • (4)Chenmeng Qiao#, Jun Yang#, Qi Shen, Ruiyuan Liu, Yanhui Li, Yuanjie Shi, Jingli Chen, Yanqin Shen, Zuobing Xiao, Jie Weng*, Xin Zhang*, Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment, Advanced Materials, 2018, 30, 1705054. (IF=32.09) 

  • (5)Ran Zhang#, Yan Li#, Bingbing Hu, Zhiguo Lu, Jinchao Zhang*, Xin Zhang*. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy. Advanced Materials, 2016, 28, 6345-6352. (IF=32.09)

  • (6)Heng Deng#, Fengying Dai#, Guanghui Ma, Xin Zhang*. Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance. Advanced Materials, 2015, 27, 3645-3653. (IF=32.09) 

  • (7)Hu Bingbing#, Dai Fengying#, Fan Zhanming, Ma Guanghui, Tang Qunwei*, Zhang Xin*. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer’s Disease in APPswe/PS1dE9 Transgenic Mice.Advanced Materials, 2015, 27: 5499-5505. (IF=32.09) 

  • (8)Weihong Ji#, Yan Li#, Huan Peng, Ruichen Zhao, Xin Zhang*.Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases. Advanced Drug Delivery Reviews, 2022, 180,114029.(IF=21.65) 

  • (9)Yan Li, Linying Liu, Weihong Ji, Huan Peng, Ruichen Zhao, Xin Zhang*. Strategies and materials of “SMART” non-viral vectors: Overcoming thebarriers for brain gene therapy. Nano Today, 2020, 35: 101006. (IF=20.24)

  • (10)Jie Shen, Jingwen Wang, Qiulian Hao, Weihong Ji, Huan Peng, Yanyue Wu, Ruichen Zhao, Xinyu Qiu, Wenl Wang, Jun Yang, Yan Li, Tianlu Zhang, Zhiguo Lu*, Xin Zhang*, Transformable Nanotheranostics Capable of Sensoring Nucleic Acid Drugs’                       Spatiotemporal    Behaviors. Advanced Functional Materials. 2023, 33, 5, 2209749. (IF=19.978) 

  • (11)Zhiguo Lu#, Yan Li#, Yuanjie Shi, Yanhui Li, Zuobing Xiao, Xin Zhang*.Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for 5 Synergistic Glioblastoma Multiforme Treatment. Advanced Functional Materials, 2017, 27, 1703967. (IF=19.97) 

  • (12)Ruiyuan Liu#, Jun Yang#, Linying Liu, Zhiguo Lu, Zhuyan Shi, Weihong Ji, Jie Shen, Xin Zhang*. An ‘Amyloid-β Cleaner’ for the Treatment of Alzheimer’s Disease by Normalizing Microglial Dysfunction. Advanced Science, 2020, 7, 1901555-1901567. (IF=18.93) 

  • (13)Huan Peng#,Yan Li#, Weihong Ji, Ruichen Zhao, Zhiguo Lu, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Jingwen Wang, Wenli Wang, Jun Yang,  Xin Zhang*.  Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson’s Disease. ACS Nano, 2022,16,1,869-884. (IF=18.02)

  • (14)Linying Liu#,Yan Li#, Huan Peng, Ruiyuan Liu,Weihong Ji, Zhuyan Shi, Jie Shen, Guanghui Ma, Xin Zhang*. Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson's disease. Science Advances, 2020, 6, 50, eaba3967. (IF=16.9) 

  • (15)Yan Li, Yanhui Li, Weihong Ji, Zhiguo Lu, Linying Liu, Yuanjie Shi, Guanghui Ma, Xin Zhang*. Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy. JACS, 2018, 140, 4164−4171. (IF=16.28)

Zhang Lab, Add: No.1, Bei-Er-Tiao, Zhong-Guan-Cun, Haidian District, Beijing China | Phone:+86-10-82544853 | Page view | 备案号:京ICP备17047136号