Institute of Process Engineering, Chinese Academy of Sciences
State Key Laboratory of Biochemical Engineering

Professor Xin Zhang

Vice-Director, State Key Lab. of Biochemical Engineering
Professor, PI, 国家优青 百人计划
National Key Laboratory of Biochemical Engineering
Institute of Process Engineering
Chinese Academy of Sciences, 100190, Beijing, P. R. China
Tel: (+86) 10 8254 4853
Fax: (+86) 10 8254 4853
Group Website:

Research Interest:
Biomaterials; Drug delivery; Diagnostic imaging; Vaccine adjuvant; Stem cell therapy

2004-2008: Ph.D. in Life Science: University of Strasbourg, FRANCE
2001-2004: M.S. in Materials: Tianjin University, CHINA
1997-2001: B.S. in Polymer Materials: Tianjin University, CHINA
Professional Experience:
2010-Present: Professor, Institute of Process Engineering, Chinese Academy of Sciences, CHINA
2008-2010: Assistant Professor, INSERM, FRANCE

Contributions within Five Years:
More than 50 research papers published in peer-reviewed journals, including Advanced Materials, Nano Letters, Theranostics, Biomaterials, and Journal of Controlled Release, which have been cited overall more than 800 times; one Chinese Book chapter entitled "Gene therapy drug mimetic membrane system" and one English Book chapter entitled " Lipopolyplex nanoparticles for tumor targeting theranostics " published at 2013 by Science Press, China, and 2014 by Higher Education Press, China, respectively; 12 patents.

Professional Affiliations:
Membership: American Chemical Society
Committee Membership: Chinese Society for Biomaterials
Committee Membership: Chinese Society of Biomedical Engineering


  • 1.Chenmeng Qiao, Jun Yang, Qi Shen, Ruiyuan Liu, Yanhui Li, Yuanjie Shi, Jingli Chen, Yanqin Shen, Zuobing Xiao, Jie Weng*, Xin Zhang*. Traceable Nanoparticles with Dual-targeting and ROS-response for RNAi-based Immunochemotherapy of Intracranial Glioblastoma Treatment. Advanced Materials, 2018, 30: 1705054. (IF=21.950)

  • 2.Zhang Ran, Li Yan, Hu Bing Bing, Lu Zhi Guo, Zhang Jin Chao*, Zhang Xin*. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy. Advanced Materials, 2016, 28: 6345-6352. (IF= 21.950)

  • 3.Deng Heng, Dai Fengying, Ma Guanghui, Zhang Xin*. Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance. Advanced Materials, 2015, 27:3645-3653. (IF= 21.950)

  • 4.Hu Bingbing, Dai Fengying, Fan Zhanming, Ma Guanghui, Tang Qunwei*, Zhang Xin*. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer’s Disease in APPswe/PS1dE9 Transgenic Mice. Advanced Materials, 2015, 27: 5499-5505. (IF= 21.950)

  • 5.Yan Li, Yanhui Li, Weihong Ji, Zhiguo Lu, Linying Liu, Yuanjie Shi, Guanghui Ma, Xin Zhang*. Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy. JACS, 2018, 140, 4164−4171. (IF=14.357)

  • 6.Zhiguo Lu, Yan Li, Yuanjie Shi, Yanhui Li, Zuobing Xiao, Xin Zhang*.Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for 5 Synergistic Glioblastoma Multiforme Treatment. Advanced Functional Materials, 2017, 27(46):1703967. (IF= 13.325)

  • 7.Yang Jun, Liu Hongmei, Zhang Xin*. Design, Preparation and application of nucleic acid delivery carriers. Biotechnology Advances, 2014, 32: 804-817. (IF= 11.452)

  • 8.Qiao Chenmeng, Yang Jun, Li Yan, Weng Jie*, Shao Yiming*, Zhang Xin*. Enhanced non-inflammasome mediated immune responses by mannosylated zwitterionic-based cationic liposomes for HIV DNA vaccines. Biomaterials, 2016, 85: 1-17. (IF=8.806)

  • 9.Li Yan, Liu Ruiyuan, Yang Jun, Shi Yuanjie, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior. Biomaterials, 2015, 41: 1-14. (IF= 8.806) 

  • 10.Li Yan, Liu Ruiyuan, Yang Jun, Ma Guanghui, Zhang Zhenzhong*, Zhang Xin*. Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy. Biomaterials, 2014, 35, 9731-9745. (IF= 8.806) 

  • 11.Liu Hongmei, Li Yan, Mozhi Anbu, Zhang Liang, Liu Yilan, Xu Xia, Xing Jianmin, Liang Xingjie, Ma Guanghui, Yang Jun*, Zhang Xin*. SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment. Biomaterials, 2014, 35: 6519-6533. (IF= 8.806) 

  • 12.Hu Bingbing, Zeng Mou, Chen Jingli, Zhang Zhenzhong, Zhang Xiaoning, Fan Zhanming*, Zhang Xin*. External magnetic field-induced targeted delivery of highly sensitive iron oxide nanocubes for MRI of myocardial infarction. Small, 2016, 34: 4707-4712. (IF= 9.598)

  • 13.Li Yan, Zhang Ruilong, Lu Zhiguo, Ma Guanghui, Chen Lei, Tang Qunwei*, Zhang Xin*. Microenvironment responsive three-pronged approach breaking traditional chemotherapy to target cancer stem cells for synergistic inoperable large tumor therapy. Small, 2016, 40: 5516-5523. (IF= 9.598)

  • 14.Li Yan, Liu Ruiyuan, Shi Yuanjie, Zhang Zhenzhong*, Zhang Xin*. Zwitterionic poly(carboxybetaine) based cationic liposomes enhancing tumor therapy without accelerated blood clearance phenomenon. Theranostics, 2015, 5: 583-596. (IF= 8.537)

  • 15.Yaqiong Dong, Jun Yang, Hongmei Liu, Tianyou Wang, Suoqin Tang, Jinchao Zhang*, Xin Zhang*. Site-specific drug-releasing polypeptide nanocarriers based on dual-pH response for enhanced therapeutic efficacy against drug-resistant tumors, Theranostics, 2015; 5(8): 890-904. (IF= 8.537)

  • 16.Deng Heng, Zhong Yanqi, Du Meihong, Liu Qingjun, Fan Zhanming*, Dai Fengying*, Zhang Xin*. Theranostic self-Assembly structure of gold nanoparticles for NIR photothermal therapy and X-ray computed tomography imaging. Theranostics, 2014, 4: 904-918. (IF= 8.537) 

  • 17.Jingli Chen, Jun Yang, Ruiyuan Liu, Chenmeng Qiao, Zhiguo Lu, Yuanjie Shi, Zhanming Fan, Zhenzhong Zhang, Xin Zhang*. Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages. Theranostics, 2017, 7, 4149-4167. (IF= 8.537)

  • 18.Li Yan1, Cheng Qiang1, Jiang Qian, Huang Yuanyu, Liu Hongmei, Zhao Yuliang, Cao Weipeng, Ma Guanghui, Dai Fengying*, Liang Xingjie*, Liang Zicai*, Zhang Xin*. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. Journal of Controlled Release, 2014, 176: 104-114. (IF= 7.786) 

  • 19.Liu Hongmei, Qiao Chenmeng, Yang Jun, Weng Jie*, Zhang Xin*. Self-assembling doxorubicin-prodrug nanoparticles as siRNA drug delivery system for cancer treatment: in vitro and in vivo. Journal of Materials Chemistry B, 2014, 2: 5910-5924. (IF=4.872)

  • 20.Zhong Yanqi1, Dai Fengying1, Deng Heng, Du Meihong, Zhang Xiaoning*, Liu Qingjun*, Zhang Xin*. A rheumatoid arthritis magnetic resonance imaging contrast agent based on folic acid conjugated PEG-b-PAA@SPION. Journal of Materials Chemistry B, 2014, 2: 2938-2946. (IF=4.872)

  • 21.Dai Fengying, Du Meihong, Liu Yingguo, Liu Guiying*, Liu Qingjun*, Zhang Xin*. Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis. Journal of Materials Chemistry B, 2014, 2: 2240-2247. (IF=4.872)      

  • 22.Ren Tianbin, Liu Qiuming, Lu Hang, Liu Hongmei, Zhang Xin*, Du Jianzhong*. Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery. Journal of Materials Chemistry, 2012, 22: 12329-12338. (IF=6.626, 分刊前) 

  • 23.Chenmeng Qiao, Jun Yang, Qi Shen, Yan-Qin Shen, JieWeng*, Xin Zhang*.RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review. Journal of Biomedical Nanotechnology, 2017, 13, 1–20. (IF= 5.068)

  • 24.Chenmeng Qiao, Jun Yang, Lei Chen,* Jie Weng*, Xin Zhang*.Intracellular accumulation and immunological responses of lipid modified magnetic iron nanoparticles in mouse antigen processing cells. Biomaterials Science, 2017, 5, 1603–1611. (IF= 4.210)

  • 25.Linying Liu, Xiaoshuang Li, Lei Chen*, Xin Zhang*, Nanoscale functional biomaterials for cancer theranostics. Current Medicinal Chemistry [J]. 2017, 24 (42). DOI: 10.2174/0929867324666170406111036.   (IF:3.455)

  • 26.Dai Fengying1, Zhang Miao1, Hu Bingbing, Sun Yongjun, Tang Qunwei, Du Meihong*, Zhang Xin*. Immunomagnetic nanoparticles based on ahydrophilic polymer coating for sensitive detection of Salmonellain raw milk by polymerase chain reaction. RSC Advances, 2015, 5: 3574-3580. (IF=3.289)    

  • 27.Liu Hongmei, Zhang Ruilong, Niu Yunwei, Li Yan, Qiao Chenmeng, Weng Jie, Li Jun, Zhang Xiaoning*, Xiao Zuobing*, Zhang Xin*. Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy. RSC Advances, 2015, 5: 20848-20857. (IF=3.289) 

  • 28.Dong Yaqiong, Yang Jun, Zhang Jinchao*, Zhang Xin*. Nano-delivery vehicles/adjuvants for DNA vaccination against HIV. Journal of Nanoscience and Nanotechnology, 2015, 15: 1-8. (IF=1.339)

  • 29.Zhang Xin, Sharma Kamal Kant, Boeglin Marcel, Ogier Joelle, Mainard Didier, Voegel Jean-Claude, Mely Yves*, Benkirane-Jessel Nadia*. Transfection ability and intracellular DNA pathway of nanostructured gene-delivery systems. Nano Letters, 2008, 8: 2432-2436. (IF= 12.080)

  • 30.Zhang Xin, Oulad-Abdelghani Mustapha, Zelkin Alexander, Wang Yajun, Haikel Youssef, Mainard Didier, Voegel Jean-Claude, Caruso Frank*, Benkirane-Jessel Nadia*. Poly(L-lysine) nanostructured particles for gene delivery and hormone stimulation. Biomaterials, 2010, 31: 1699-1706. (IF= 8.806)

  • 31.Zhang Xin, Kovtun Anna, Mendoza-Palomares Carlos, Oulad-Abdelghani Mustapha, Fioretti Florence, Rinckenbach Simon, Mainard Didier, Epple Matthias, Benkirane-Jessel Nadia*. SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing. Biomaterials, 2010, 31: 6013-6018. (IF= 8.806)

Zhang Lab, Add: No.1, Bei-Er-Tiao, Zhong-Guan-Cun, Haidian District, Beijing China | Phone:+86-10-82544853 | Page view | Visitor