Institute of Process Engineering, Chinese Academy of Sciences
State Key Laboratory of Biochemical Engineering

Professor Xin Zhang

Vice-Director, State Key Lab. of Biochemical Engineering
Professor, PI, 国家优青 
National Key Laboratory of Biochemical Engineering
Institute of Process Engineering
Chinese Academy of Sciences, 100190, Beijing, P. R. China
Tel: (+86) 10 8254 4853
Fax: (+86) 10 8254 4853
Group Website:

Research Interest:
Biomaterials; Drug delivery; Diagnostic imaging; Vaccine adjuvant; Stem cell therapy

2004-2008: Ph.D. in Life Science: University of Strasbourg, FRANCE
2001-2004: M.S. in Materials: Tianjin University, CHINA
1997-2001: B.S. in Polymer Materials: Tianjin University, CHINA
Professional Experience:
2010-Present: Professor, Institute of Process Engineering, Chinese Academy of Sciences, CHINA
2008-2010: Assistant Professor, INSERM, FRANCE

Contributions within Five Years:
More than 50 research papers published in peer-reviewed journals, including Advanced Materials, Nano Letters, Theranostics, Biomaterials, and Journal of Controlled Release, which have been cited overall more than 800 times; one Chinese Book chapter entitled "Gene therapy drug mimetic membrane system" and one English Book chapter entitled " Lipopolyplex nanoparticles for tumor targeting theranostics " published at 2013 by Science Press, China, and 2014 by Higher Education Press, China, respectively; 12 patents.

Professional Affiliations:
Membership: American Chemical Society
Committee Membership: Chinese Society for Biomaterials
Committee Membership: Chinese Society of Biomedical Engineering


  • 1.      Ran Zhang#, Yan Li#, Bingbing Hu, Zhiguo Lu, Jinchao Zhang*, Xin Zhang*. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy. Advanced Materials, 2016, 28: 6345-6352. (IF= 25.809)

  • 2.      Heng Deng#, Fengying Dai#, Guanghui Ma, Xin Zhang*. Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance. Advanced Materials, 2015, 27:3645-3653. (IF= 25.809)

  • 3.      Binging Hu#, Fengying Dai#, Zhanming Fan, Guanghui Ma, Qunwei Tang*, Xin Zhang*. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer’s Disease in APPswe/PS1dE9 Transgenic Mice. Advanced Materials, 2015, 27: 5499-5505. (IF= 25.809)

  • 4.      Chenmeng Qiao#, Jun Yang#, Qi Shen, Ruiyuan Liu, Yanhui Li, Yuanjie Shi, Jingli Chen, Yanqin Shen, Zuobing Xiao, Jie Weng*, Xin Zhang*, Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment, Advanced Materials, 2018, 30: 1705054. (IF= 25.809)

  • 5.      Yan Li, Yanhui Li, Weihong Ji, Zhiguo Lu, Linying Liu, Yuanjie Shi, Guanghui Ma, Xin Zhang*. Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy. JACS, 2018, 140, 4164−4171. (IF= 14.695)

  • 6.      Linying Liu#, Yan Li#, Ruiyuan Liu, Qi Shen, Yanhui Li, Zhuyan Shi, Jie Shen, Weihong Ji, Xin Zhang*. Switchable Nanoparticle for Programmed Gene-chem Delivery with Enhanced Neuronal Recovery and CT Imaging for Neurodegenerative Disease Treatment. Materials Horizons, 2019, 2019, 6, 1923-1929. (IF=14.356)

  • 7.      Qi Shen#, Jun Yang#, Ruiyuan Liu, Linying Liu, Jinchao Zhang, Shigang Shen *, Xin Zhang*. Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy. Materials Horizons, 2019, 6, 810-816. (IF=14.356)

  • 8.      Ruiyuan Liu#, Jun Yang#, Linying Liu, Zhiguo Lu, Zhuyan Shi, Weihong Ji, Jie Shen, Xin Zhang*. An ‘Amyloid-β Cleaner’ for the Treatment of Alzheimer’s Disease by Normalizing Microglial Dysfunction. Advanced Science, 2020, 7, 1901555. (IF=15.804)

  • 9.      Zhiguo Lu#, Yan Li#, Yuanjie Shi, Yanhui Li, Zuobing Xiao, Xin Zhang*.Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for 5 Synergistic Glioblastoma Multiforme Treatment. Advanced Functional Materials, 2017, 27(46):1703967. (IF=15.621)

  • 10.   Jun Yang, Hongmei Liu, Xin Zhang*. Design, Preparation and application of nucleic acid delivery carriers. Biotechnology Advances, 2014, 32: 804-817. (IF=12.231)

  • 11.   Xin Zhang, Kamal Kant Sharma, Marcel Boeglin, Joelle Ogier, Didier Mainard, Jean-Claude Voegel, Yves Mély* , Nadia Benkirane-Jessel*. Transfection ability and intracellular DNA pathway of nanostructured gene-delivery systems. Nano Letters, 2008, 8: 2432-2436. (IF=12.279)

  • 12.   Bingbing Hu, Mou Zeng, Jingli Chen, Zhenzhong Zhang, Xiaoning Zhang, Zhanming Fan *, Xin Zhang*. External magnetic field-induced targeted delivery of highly sensitive iron oxide nanocubes for MRI of myocardial infarction. Small, 2016, 34: 4707-4712. (IF=10.856)

  • 13.   Yan Li#, Ruilong Zhang#, Zhiguo Lu, Guanghui Ma, Lei Chen, Qunwei Tang*, Xin Zhang*. Microenvironment responsive three-pronged approach breaking traditional chemotherapy to target cancer stem cells for synergistic inoperable large tumor therapy. Small, 2016, 40: 5516-5523. (IF=10.856)

  • 14.   Chenmeng Qiao#, Jiandong Liu#, Jun Yang#, Yan Li, Jie Weng*, Yiming Shao*, Xin Zhang*. Enhanced non-inflammasome mediated immune responses by mannosylated zwitterionic-based cationic liposomes for HIV DNA vaccines. Biomaterials, 2016, 85: 1-17. (IF=10.273)

  • 15.   Yan Li#, Ruiyuan Liu#, Jun Yang, Yuanjie Shi, Guanghui Ma, Zhenzhong Zhang*, Xin Zhang*. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior. Biomaterials, 2015, 41: 1-14. (IF=10.273)

  • 16.   Yan Li, Ruiyuan Liu, Jun Yang, Guanghui Ma, Zhenzhong Zhang*, Xin Zhang*. Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy. Biomaterials, 2014, 35, 9731-9745. (IF=10.273)

  • 17.   Hongmei Liu, Yan Li, Anbu Mozhi, Liang Zhang, Yilan Liu, Xia Xu, Jianmin Xing, Xingjie Liang, Guanghui Ma, Jun Yang*, Xin Zhang*. SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment. Biomaterials, 2014, 35: 6519-6533. (IF=10.273)

  • 18.   Xin Zhang#, Mustapha Oulad-Abdelghani#, Alexander N. Zelkin, Yajun Wang , Youssef Haıˆkel, Didier Mainard, Jean-Claude Voegel, Frank Caruso c*, Nadia Benkirane-Jessel*. Poly(L-lysine) nanostructured particles for gene delivery and hormone stimulation. Biomaterials, 2010, 31: 1699-1706. (IF=10.273)

  • 19.   Xin Zhang# , Anna Kovtun# , Carlos Mendoza-Palomares# , Mustapha Oulad-Abdelghani# , Florence Fioretti , Simon Rinckenbach, Didier Mainard, Matthias Epple*, Nadia Benkirane-Jessel*. SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing. Biomaterials, 2010, 31: 6013-6018. (IF=10.273)

  • 20.   Yaqiong Dong#, Jun Yang#, Hongmei Liu, Tianyou Wang, Suoqin Tang, Jinchao Zhang*, Xin Zhang*. Site-specific drug-releasing polypeptide nanocarriers based on dual-pH response for enhanced therapeutic efficacy against drug-resistant tumors, Theranostics, 2015; 5(8): 890-904. (IF=8.063)

  • 21.   Heng Deng, Yanqi Zhong, Meihong Du, Qingjun Liu, Zhanming Fan*, Fengying Dai*, Xin Zhang*. Theranostic self-Assembly structure of gold nanoparticles for NIR photothermal therapy and X-ray computed tomography imaging. Theranostics, 2014, 4: 904-918. (IF=8.063)

  • 22.   Jingli Chen#, Jun Yang#, Ruiyuan Liu, Chenmeng Qiao, Zhiguo Lu, Yuanjie Shi, Zhanming Fan, Zhenzhong Zhang*, Xin Zhang*. Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages. Theranostics, 2017,17:4149-4167. (IF=8.063)

  • 23.   Yan Li#, Ruiyuan Liu#, Yuanjie Shi, Zhenzhong Zhang*, Xin Zhang*. Zwitterionic poly(carboxybetaine) based cationic liposomes enhancing tumor therapy without accelerated blood clearance phenomenon. Theranostics, 2015, 5: 583-596. (IF=8.063)

  • 24.   Yanhui Li, Zixuan Chen, Zhiguo Lu, Qinghu Yang, Linying Liu, Zhaotan Jiang, Liqun Zhang, Xin Zhang*, Hong Qing*. “Cell-addictive” dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway. Theranostics, 2018,8:5469-5481. (IF=8.063)

  • 25.   Jun Yang#, Zhuyan Shi#, Ruiyuan Liu, Yanyue Wu, Xin Zhang*.Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology. Theranostics, Accepted. (IF=8.063)

  • 26.   Yan Li#, Qiang Cheng#, Qian Jiang, Yuanyu Huang, Hongmei Liu, Yuliang Zhao, Weipeng Cao, Guanghui Ma, Fengying Dai*, Xingjie Liang*, Zicai Liang*, Xin Zhang*. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. Journal of Controlled Release, 2014, 176: 104-114. (IF=7.901)

  • 27.   Yan Li, Ruiyuan Liu, Weihong Ji, Yanhui Li, Linying Liu, Xin Zhang*. Delivery systems for theranostics in neurodegenerative diseases. Nano Research.2018, 11, 5535–5555. (IF=8.515)

  • 28.   Tianbin Ren, Qiuming Liu, Hang Lu, Hongmei Liu, Xin Zhang*, Jianzhong Du*. Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery. Journal of Materials Chemistry, 2012, 22: 12329-12338. (IF=6.641)

Zhang Lab, Add: No.1, Bei-Er-Tiao, Zhong-Guan-Cun, Haidian District, Beijing China | Phone:+86-10-82544853 | Page view | 备案号:京ICP备17047136号